Educational Background
September 2001 - January 2007, Department of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Master-Doctor Continuation Program
September 1997 - July 2001, China University of Geosciences (Wuhan), Bachelor's Degree
Work Experience
April 2019 - Present, Xiamen University, School of Public Health, Associate Professor
July 2010 - March 2019, Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Associate Researcher
June 2009 - June 2010, Chemical Safety Bureau, Health Canada, Canada, Visiting Fellow
April 2007 - April 2009, Xiamen University, School of Chemistry and Chemical Engineering, Postdoc
Major Research Areas
Clinical Medicine: Utilizing systems epidemiology and multi-omics methods to identify biomarkers, biological targets, and metabolic pathways, deeply exploring the pathogenesis of diseases, establishing early prediction and high-risk individual screening models, providing scientific support fo personalized medicine and translational medicine; developing in vitro diagnostic methods based on biomarker discovery and realizing clinical application.
Environmental Medicine: Based on transcriptomics, gut microbiome, epigenomics, proteomics, and metabolomics, combining exposome with systems epidemiology, studying the association and molecular mechanism of environmental factors (environmental exposure, nutrition, lifestyle, etc.) with diseases, preventing diseases and promoting health in a precise manner.
Public Health Emergency Platform Construction: High-throughput analysis technology for harmful substances in complex samples (food, biological samples, environmental samples)
Representative Achievements
Scientific research projects:
National Natural Science Foundation of China, 22076157, Arsenic-induced liver glucose and lipid metabolism disorders promote/aggravate gestational diabetes: mechanism and intervention studies, 630,000 RMB, Head.
National Natural Science Foundation of China, 21677141, Reproductive toxicity studies on adolescent arsenic exposure interfering with the endocrine/metabolic pathway in the HPT axis of male rats, 650,000 RMB, Head.
National Natural Science Foundation of China, Youth Project, 21407143, Influences and interference mechanism studies on drinking water arsenic exposure on hippocampus and cortical DNA methylation/demethylation process in young mice, 260,000 RMB, Head.
National Key R&D Program of the Ministry of Science and Technology, 2017YFC0211602, Early Identification Technology for the Impact of Air Pollution on Respiratory and Cardiovascular System Health, 29.67 million RMB, Core member.
Xiamen University President's Fund Project, 20720190074, Male Reproductive Health Research based on "Exposome-Metabolome-Sperm Quality" Full Correlation Analysis, 750,000 RMB, Head.
Youth Innovation Promotion Association Talent Project, Chinese Academy of Sciences, January 2015 - December 2018, 600,000 RMB, Head.
Important Direction Project of Knowledge Innovation Engineering, Chinese Academy of Sciences, KZCX2-EW-QN408, Human Liver Cell Toxicity Studies on Perfluorooctane Pollutants Based on Joint Omics, 1.2 million RMB, Head.
Xiamen Science and Technology Plan Project, 3502Z20112017, High Throughput Screening Detection Technology Research on Organic Pollutants in Milk and Dairy Products, 1 million RMB, Head.
Fujian Provincial Natural Science Foundation Project, 2018J01021, System Biology Method to Study the Interference Effects and Mechanisms of Air Particulates on the Lung Microbiome and Its Interaction Network with the Host Molecule, 60,000 RMB, Head.
Fujian Provincial Natural Science Foundation Project, 2013J01063, Dietary Exposure and Health Risk of Typical Phenolic Environmental Estrogens in Fujian Province, 60,000 RMB, Head.
Frontier Project for Young Talents, Institute of Urban Environment, Chinese Academy of Sciences, IUEZD201401, Endocrine (Hormonal) and Metabolic Interference Effects and Mechanism Studies Based on Hypothalamic-Pituitary-Testicular Gonadal Axis, 400,000 RMB, Head.
Representative papers published in recent years: Corresponding author, #First author*
1. Zhong-Hua Lu#, Bin Sun#, Yi-Xin Wang*, Ya-Ru Wu, Yu-Jie Chen, Sheng-Zhi Sun, Shi-Jia Liang, Song Xu, Hao Chang, Heng-Gui Chen, Jie Zhang*, Ozone exposure associates with sperm quality indicators: Sperm telomere length as a potential mediating factor, Journal of Hazardous Materials. 2023, 459: 132292.
2. Rui Guo#, Qisheng Zhong, Jiaqi Liu, Peiming Bai, Zongpeng Wang, Jieling Kou, Peijie Chen*, Jie Zhang*, Bo Zhang*. Polarity-extended liquid chromatography-triple quadrupole mass spectrometry for simultaneous hydrophilic and hydrophobic metabolite analysis, Analytica Chimica Acta 2023, 1277: 341655.
3. Long-term ozone exposure was negatively associated with estimated glomerular filtration rate in Chinese middle-aged and elderly adults. Chemosphere 2023, 341：140040
4. Tasawar Khanam#, Shijia Liang#, Song Xu, Syed Ali Musstjab Akber Shah Eqani*, Mustafa Nawaz Shafqat, Hifza Rasheed, Nazia Bibi, Heqing Shen, Jie Zhang*, Arsenic exposure induces urinary metabolome disruption in Pakistani male population, Chemosphere 2023, 312: 137228.
5. Song Xu#, Yaru Wu, Yujie Chen, Wenqing Lu, Yi-Xin Wang⁎, Biling Gao, Jie Zhang ⁎, Environmental metal exposure, seminal plasma metabolome and semen quality: Evidence from Chinese reproductive-aged men, Science of the Total Environment 2022, 838: 155860.
6. Xiaoyan Du, Lianzhong Luo, Qingyu Huang, Jie Zhang⁎, Cortex metabolome and proteome analysis reveals chronic arsenic exposure via drinking water induces developmental neurotoxicity through hnRNP L mediated mitochondrial dysfunction in male rats, Science of the Total Environment 2022, 820: 153325.
7. Chen Tang#, Hanxiang Jiang#, Bin Zhao#, Yi Lin, Shengnan Lin, Tianmu Chen, Yanhua Su, Yiqin Zhang, Lina Zhou, Lianmeng Li, Jincheng Lin, Zhonghua Lu, Yao Wang, Zeyu Zhao, Longjian Liu, Yuxin Wang*, Jie Zhang*, Heqing Shen*, The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study, Journal of Translational Medicine 2022, 20:108.
8. Xuejingping Han#, Meiping Tian#, Pavel V. Shliaha, Jie Zhang*, Shoufang Jiang, Bingru Nan, Md Nur Alam, Ole N. Jensen*, Heqing Shen, Qingyu Huang*, Real-world particulate matters induce lung toxicity in rats fed with a high-fat diet: Evidence of histone modifications, Journal of Hazardous Materials 2021, 416: 126182.
9. Xiaoyan Du, Jie Zhang⁎, Xi Zhang, Karl-Werner Schramm, Bingru Nan, Qingyu Huang, Meiping Tian, Heqing Shen⁎, Persistence and reversibility of arsenic-induced gut microbiome and metabolome shifts in male rats after 30-days recovery duration, Science of the Total Environment 2021, 776: 145972.
10. Tasawar Khanam, Syed Ali Musstjab Akber Shah Eqani, Jie Zhang⁎, Heng Wang, Yongli Zhang, Jianbo Yang, Muhammad Sadiq, Hifza Rasheed, Heqing Shen⁎, Urinary profiles of selected metals and arsenic and their exposure pathway analysis in four large floodplains of Pakistan, Science of the Total Environment 2020, 737: 139586.
11. Yi-Xin Wang, Yan Wu, Heng-Gui Chen, Peng Duan, Liang Wang, He-Qing Shen, Wen-Qing Lu, Bin Sun, Qi Wang, Bo Zhang, Jorge E. Chavarro, Jie Zhang(*), An Pan(*), Seminal Plasma Metabolome in Relation to Semen Quality and Urinary Phthalate Metabolites among Chinese Adult Men, Environment International, 2019, 129: 354–363.
12. Yan Wu(#), Jie Zhang(#), Siyuan Peng, Xiaofei Wang, Lianzhong Luo, Liangpo Liu, Qingyu Huang, Meiping Tian, Xueqin Zhang(*), Heqing Shen(*), Multiple elements related to metabolic markers in the context of gestational diabetes mellitus in meconium, Environment International, 2018, 121: 1227–1234.
13. Jie Zhang(*), Liangpo Liu, Xiaofei Wang, Qingyu Huang, Meiping Tian, and Heqing Shen(*), Low-Level Environmental Phthalate Exposure Associates with Urine Metabolome Alteration in a Chinese Male Cohort, Environmental Science & Technology, 2016, 50: 5953-60.
14. Jie Zhang, Heqing Shen(*), Weipan Xu, Yankai Xia, Dana Boyd Barr, Xiaoli Mu, Xiaoxue Wang, Liangpo Liu, Qingyu Huang, and Meiping Tian, Urinary Metabolomics Revealed Arsenic Internal Dose-related Metabolic Alterations: a Proof-of-Concept Study in a Chinese Male Cohort, Environmental Science & Technology, 2014, 48(20): 12265-74.
15. Xiaoyan Du, Meiping Tian, Xiaoxue Wang, Jie Zhang(*), Qingyu Huang, Liangpo Liua, Heqing Shen(*), Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water, Environmental Pollution, 2018, 234:590-600.
16. Xiaofei Wang, Liangpo Liu, Weibing Zhang(*), Jie Zhang(*), Xiaoyan Du, Qingyu Huang, Meiping Tian, Heqing Shen(*), Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative /nitrosative stress in humans, Environmental Pollution, 2017, 229: 168-176.
17. Xiaofei Wang, Shoufang Jiang, Ying Liu, Xiaoyan Du, Weibing Zhang(*), Jie Zhang(*), Heqing Shen(*),Comprehensive pulmonary metabolome responses to intratracheal instillation of airborne fine particulate matter in rats, Science of the Total Environment, 2017, 592：41-50.
18. Xiaofei Wang(#), Jie Zhang(#), Weipan Xu, Qingyu Huang, Liangpo Liu, Meiping Tian, Yankai Xia, Weibing Zhang(*), Heqing Shen(*), Low-level environmental arsenic exposure correlates with unexplained male infertility risk, Science of the Total Environment, 2017, 571(15): 307~313.
19. Jie Zhang(*), Xiaoli Mu, Weipan Xu, Francis L. Martin, Ambreen Alamdar, Liangpo Liu, Meiping Tian, Qingyu Huang, Heqing Shen(*), Exposure to Arsenic via Drinking Water Induces 5-Hydroxymethylcytosine Alteration in Rat, Science of Total Environment, 2014, 497: 618-625.
20. Jie Zhang, Zhenzhen Huang, Minjian Chen, Yankai Xia, Francis L Martin, Weipan Xu, Wei Hang, Heqing Shen(*), Urinary Metabolome Identifies Signatures of Oligozoospermic Infertile Men, Fertility and Sterility, 2014, 102(1): 44-53.
21. Siyuan Peng(#), Jie Zhang(#), Liangpo Liu, Xueqing Zhang, Qingyu Huang, Ambreen Alamdar, Meiping Tian, Heqing Shen (*), Newborn Meconium and Urinary Metabolome Response to Maternal Gestational Diabetes Mellitus: A Preliminary Case-Control Study, Journal of Proteome Research, 2015, 14, 1799-1809.
22. Jie Zhang, Zhenzhen Huang, Yankai Xia, Francis L Martin, Wei Hang, Heqing Shen(*), Metabolomic Analysis Reveals a Unique Urinary Pattern in Normozoospermic Infertile Men, Journal of Proteome Research, 2014, 13(6): 3088-99.
23. Xiaoxue Wang, Xiaoli Mu, Jie Zhang(*), Qingyu Huang, Ambreen Alamdar, Meiping Tian, Liangpo Liu, Heqing Shen(*), Serum metabolomics reveals arsenic exposure disrupted lipid and amino acid metabolism in rat: a step forward in understanding chronic arsenic toxicity, Metallomics, 2015, 7(3): 544-552.
24. Qingyu Huang, Jie Zhang(*), Francis L Martin, Siyuan Peng, Meiping Tian, Xiaoli Mu, Heqing Shen(*), Perfluorooctanoic Acid Induces Apoptosis through the p53-Dependent Mitochondrial Pathway in Human Hepatic Cells: A Proteomic Study, Toxicology Letters, 2013, 223(2): 211-220.
25. Xiaoxue Wang, Jie Zhang(*), Qingyu Huang, Ambreen Alamdar, Meiping Tian, Liangpo Liu, Heqing Shen(*), Serum Metabolomics Analysis Reveals Oral Exposure to Benzo(a)pyrene Impaired Lipid Metabolism in Rats, Molecular Biosystems, 2015, 11: 753-759.
26. Qingyu Huang, Jie Zhang(*), Siyuan Peng, Heqing Shen(*), Proteomic analysis of perfluorooctane sulfonate-induced apoptosis in human hepatic cells using the iTRAQ technique, Journal of Applied Toxicology, 2014, 34(12): 1342-51.
27. Qingyu Huang, Jie Zhang(*), Siyuan Peng, Meiping Tian, Jinsheng Chen, Heqing Shen(*), Effects of Water Soluble PM2.5 Extracts Exposure on Human Lung Epithelial cells (A549): a Proteomic Study, Journal of Applied Toxicology, 2014, 34(6): 675-687.
28. Siyuan Peng, Lijuan Yan, Jie Zhang(*), Zhanlin Wang, Meiping Tian, Heqing Shen(*), An Integrated Metabonomics and Transcriptomics Approach to Understanding Metabolic Pathway Disturbance Induced by Perfluorooctanoic acid, Journal of Pharmaceutical and Biomedical Analysis, 2013, 86: 56-64.
29. Jie Zhang, Lijuan Yan, Meiping Tian, Qingyu Huang, Siyuan Peng, Sijun Dong(*), Heqing Shen(*), The Metabonomics of Combined Dietary Exposure to Phthalates and Polychlorinated Biphenyls in Mice, Journal of Pharmaceutical and Biomedical Analysis, 2012, 66: 287-297.
Awards, Honors, and Social Appointments
Double-Hundred Talents of Xiamen City
Young Committee Member of the Respiratory Toxicology Branch of the Chinese Society of Toxicology
Member of the Food Safety Committee of Xiamen
