Research interest: Radioisotope labeling and radiopharmaceuticals

Mailing address: 412 Molecular Imaging Building, Xiang'an Campus, Xiamen University, No. 4221-116 Xiang'an South Road, Xiang'an District, Xiamen City, Fujian Province

Biography

In 2014, Dr. Li Zijing earned her Ph.D. in Inorganic Chemistry from the College of Chemistry at Beijing Normal University, under the guidance of Prof. Liu Boli, an academician from the Chinese Academy of Engineering. Shortly thereafter, she became a PI of the Center of Molecular Imaging and Translational Medicine at the School of Public Health, Xiamen University, starting in August 2014. Throughout her career, Dr. Li Zijing has devoted her efforts to investigating radiolabeling techniques using halogen isotopes and exploring novel imaging tracers.

Publication

[26] Xiaowei Fan, Xiaoxiao Wang, Zijing Li*, Yesen Li*. ⁶⁸Ga-Labeled TMTP1 derivatives with moderate hydrophilicity for positron emission tomography of hepatocellular carcinoma in high contrast. J. Med. Chem., 2023, https://doi.org/10.1021/acs.jmedchem.3c00111

[25] Kaiqiang Zhang, Wanru Feng, Zhaobiao Mou, Jiayin Chen, Xiaoqun Tang, Zijing Li*. ¹⁸F-Labeling Chemistry in Aqueous Media. Chem.-Eur. J., 2023, https://doi.org/10.1002/chem.202300248

[24] Xiaoxiao Wang, Tao Wang, Xiaowei Fan, Zhao Zhang, Yingwei Wang*, Zijing Li*. A Molecular Toolbox of Positron Emission Tomography Tracers for General Anesthesia Mechanism Research. J. Med. Chem., 2023, https://doi.org/10.1021/acs.jmedchem.2c01965

[23] Zixiao Zhao, Jie Wang, Ying Wang, Xia Liu, Kun He, Qihao Guo*, Fang Xie*, Qi Huang*, Zijing Li*. ¹⁸F-AV45 PET and MRI reveal the influencing factors of AD biomarkers in subjective cognitive decline population. J. Alzheimers Dis., 2023, https://doi.org/10.3233/JAD-221251

[22] Tao Wang, Shengji Lv, Zhaobiao Mou, Zhenru Zhang, Taotao Dong, Zijing Li*. Isotope exchange-based ¹⁸F-labeling methods. Bioconjugate Chem., 2023, 34, 1, 140–161. https://doi.org/10.1021/acs.bioconjchem.2c00530

[21] Hongzhang Yang, Lei Zhang, Huanhuan Liu, Yunming Zhang, Zhaobiao Mou, Xueyuan Chen, Jingchao Li, Fang Xie, Fengming He, Zijing Li*. Simplified one-pot ¹⁸F-labeling of biomolecules with in situgenerated fluorothiophosphate synthons in high molar activity. Theranostics, 2023, 13, 2, 472–482. https://doi.org/10.7150/thno.79452

[20] Lumei Huang, Zijing Li*, Xianzhong Zhang*. Radiotracers for Nuclear Imaging of Reactive Oxygen Species: Advances Made so Far. Bioconjugate Chem., 2022, 33, 5, 749–766. https://doi.org/10.1021/acs.bioconjchem.2c00050

[19] Yanfang Huang, Huanhuan Liu, Xueyuan Chen, Yunming Zhang, Xingyang Zhao, Wenchao Huang, Zhaobiao Mou, Chao Wang, Kaiqiang Zhang, Zijing Li*. Small-Molecule Absorber A1094 as a Stable and Fast-Clearing NIR-II Imaging Agent. ChemMedChem, 2021, 16, 16, 2497–2503. https://doi.org/10.1002/cmdc.202100125

[18] Chao Wang, Lei Zhang, Zhaobiao Mou, Wanru Feng, Zhongjing Li, Hongzhang Yang, Xueyuan Chen, Shengji Lv, Zijing Li*. Direct ¹⁸F-Labeling of Biomolecules via Spontaneous Site-specific Nucleophilic Substitution by F⁻ on Phosphonate Prostheses. Org. Lett., 2021, 23, 11, 4261–4266. https://doi.org/10.1021/acs.orglett.1c01211

[17] Zhaobiao Mou, Xueyuan Chen, Chao Wang, Tao Wang, Hongzhang Yang, Zijing Li*. Nucleophilic ¹⁸F-fluorination of phosphorofluoridates and phosphonofluoridic acids via imidazole-activated precursors. Tetrahedron Lett., 2021, 68, 152917. https://doi.org/10.1016/j.tetlet.2021.152917

[16] Xueyuan Chen, Qiuyang Zhang, Yunming Zhang, Jianyang Fang, Donglang Jiang, Zhaobiao Mou, Huanhuan Liu, Rong Su, Chao Wang, Fengming He, Xiaochun Chen*, Fang Xie*, Xiaodong Pan*, Zijing Li*. ¹⁸F-Labelled pyrrolopyrimidines reveal brain leucine-rich repeat kinase 2 expression implicated in Parkinson’s disease. Eur. J. Med. Chem., 2021, 214, 113245. https://doi.org/10.1016/j.ejmech.2021.113245

[15] Hua Li, Lumei Huang, Hailong Jiang, Jianyang Fang, Zhide Guo, Fei Gao, Mei Chen, Duo Xu, Zijing Li*, Xianzhong Zhang*. Controllable stripping of radiolabeled group in vivo to optimize nuclear imaging via NO-responsive bioorthogonal cleavage reaction. RSC Adv., 2020, 10, 40030–40034. https://doi.org/10.1039/D0RA07186B

[14] Chunyan Li* Wanfei Li, Huanhuan Liu, Yejun Zhang, Guangcun Chen, Zijing Li*, Qiangbin Wang*. Activatable NIR-II Nanoprobe for In Vivo Early Real-Time Diagnosis of Traumatic Brain Injury. Angew. Chem. Int. Ed., 2019, 59, 1, 247–252. https://doi.org/10.1002/anie.201911803

[13] Huanhuan Liu, Xiangyu Wang, Yanfang Huang, Honghui Li, Chenyu Peng, Hongzhang Yang, Jindian Li, Huawei Hong, Zhao Lei, Xiaofen Zhang, Zijing Li*. Biocompatible Croconaine Aggregates with Strong 1.2–1.3 μm Absorption for NIR-IIa Photoacoustic Imaging in Vivo. ACS Appl. Mater. Interfaces, 2019, 11, 34, 30511–30517. https://doi.org/10.1021/acsami.9b06824

[12] Hualong Fu, Weiting Tang, Zhen Chen, Vasily V. Belov, Genwei Zhang, Tuo Shao, Xiaofei Zhang, Qingzhen Yu, Jian Rong, Xiaoyun Deng, Wei Han, Scott Myers, Pilar Giffenig, Lu Wang, Lee Josephson, Yihan Shao, April Davenport, James Daunais, Mikhail I Papisov, Hongjie Yuan, Zijing Li*, Stephen F. Traynelis*; Steven H Liang*. Synthesis and Preliminary Evaluations of a Triazole-cored Antagonist ([¹⁸F]N2B-0518) as PET Imaging Probe for GluN2B Subunit in the Brain. ACS Chem. Neurosci., 2019, 10, 5, 2263–2275. https://doi.org/10.1021/acschemneuro.8b00591

[11] Yajing Liu, Huanhuan Liu, Huixiang Yan, Yingchao Liu, Jinsen Zhang, Wenjun Shan, Puxiang Lai, Honghui Li, Lei Ren, Zijing Li*, Liming Nie*. Aggregation-Induced Absorption Enhancement for Deep Near-Infrared II Photoacoustic Imaging of Brain Gliomas In Vivo. Adv. Sci., 2019, 6, 8, 1801615. https://doi.org/10.1002/advs.201801615

[10] Huawei Hong, Lei Zhang, Fang Xie, Rongqiang Zhuang, Donglang Jiang, Huanhuan Liu, Jindian Li, Hongzhang Yang, Xianzhong Zhang, Liming Nie*, Zijing Li*. Rapid one-step ¹⁸F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors. Nat. Commun., 2019, 10, 989. https://doi.org/10.1038/s41467-019-08953-0

[9] Hualong Fu, Zhen Chen, Lee Josephson, Zijing Li*, Steven H. Liang*. Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N‑Methyl‑D‑aspartate (NMDA), α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors. J. Med. Chem. 2019, 62, 2, 403–419. https://doi.org/10.1021/acs.jmedchem.8b00714

[8] Lumei Huang, Zijing Li*, Deliang Zhang, Hua Li, Changrong Shi, Pu Zhang, Xinhui Su, Xianzhong Zhang*. Highly Specific and Sensitive Radioiodinated Agent for In Vivo Imaging of Superoxide through Superoxide-initiated Retention. Anal. Chem. 2018, 90, 21, 12971–12978. https://doi.org/10.1021/acs.analchem.8b03642

[7] Longguang Tang, Chenyu Peng, Bowen Tang, Zijing Li*, Xiangyu Wang, Jindian Li, Fei Gao, Lumei Huang, Duo Xu, Pu Zhang, Rongqiang Zhuang, Xinhui Su, Xiaoyuan Chen, Xianzhong Zhang*. Radioiodinated Small Molecule Tyrosine Kinase Inhibitor for HER2-Selective SPECT Imaging. J. Nucl. Med., 2018, 59(9), 1386–1391. https://doi.org/10.2967/jnumed.117.205088

[6] Yajing Liu, Yanping Yang, Mingjian Sun, Mengchao Cui, Ying Fu, Yu Lin, Zijing Li*, Liming Nie*. Highly specific noninvasive photoacoustic and positron emission tomography of brain plaque with functionalized croconium dye labeled by a radiotracer. Chem. Sci., 2017, 8, 2710–2716. https://doi.org/10.1039/C6SC04798J

[5] Hua Li, Deliang Zhang, Mengna Gao, Lumei Huang, Longguang Tang, Zijing Li*, Xiaoyuan Chen, Xianzhong Zhang*. Highly specific C-C bond cleavage induced FRET fluorescence for in vivo biological nitric oxide imaging. Chem. Sci., 2017, 8, 2199–2203. https://doi.org/10.1039/C6SC04071C

[4] Zijing Li*, Xuran Zhang, Xiaoyang Zhang, Mengchao Cui, Jie Lu, Xiaodong Pan*, Xianzhong Zhang*. 18F-Labeled Benzyldiamine Derivatives as Novel Flexible Probes for Positron Emission Tomography of Cerebral β-Amyloid Plaques. J. Med. Chem., 2016, 59, 23, 10577–10585. https://doi.org/10.1021/acs.jmedchem.6b01063

[3] Zijing Li, Mengchao Cui*, Jinming Zhang*, Jiapei Dai, Xiaojun Zhang, Peng Chen, Hongmei Jia, Boli Liu. Novel ¹⁸F-labeled dibenzylideneacetone derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques. Eur. J. Med. Chem., 2014, 84, 628–638. https://doi.org/10.1016/j.ejmech.2014.07.070

[2] Zijing Li, Mengchao Cui*, Jiapei Dai, Xuedan Wang, Pingrong Yu, Yanping Yang, Jianhua Jia, Hualong Fu, Masahiro Ono, Hongmei Jia, Hideo Saji, Boli Liu*. Novel Cyclopentadienyl Tricarbonyl Complexes of ^99mTc Mimicking Chalcone as Potential Single-Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Brain. J. Med. Chem., 2013, 56, 2, 471–482. https://doi.org/10.1021/jm3014184

[1] Zi-Jing Li, Hui-Ying Ren, Meng-Chao Cui, Winnie Deuther-Conrad, Rui-Kun Tang, Jörg Steinbach, Peter Brust, Bo-Li Liu, Hong-Mei Jia*. Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging. Bioorgan. Med. Chem., 2011, 19, 9, 2911–2917. https://doi.org/10.1016/j.bmc.2011.03.037