Education

BE, Biology, Ocean University of China (2003-2007)

MS, Food Science, Ocean University of China (2007-2010)

PhD, Food Science, Ocean University of China (2010-2014)

Visiting Student, Division of Endocrinology, Metabolism, and Lipid Research, Washington University in St. Louis (2011-2013)

Research Interest

We use transgenic mouse and cell lines to understand the crosstalk between metabolism and cell function during pregnancy and metabolic syndromes.

First, we are interested the role of metabolism in normal pregnancy，and how metabolic dysfunction lead to adverse maternal-fetal outcomes. Besides, we focused on the multiple effects of dietary factors on metabolic syndrome, including beneficial components (nutrients, bioactives) and harmful components.

Grants

National Science Fund for Distinguished Young Scholars (31601559) PI;

Xiamen Science Fund (3502Z202372001) PI;

National Key Research and Development Program of China (2022YFC2704700, 2018YFC1004103) Participant;

Publications (Last 5 years)

1. Yu Miao†, Hu Xiaoqian†, Pan, Zihang, Du Cui; Jiang Jing, Zheng Wanshan, Cai Han, Wang Yinan, Deng Wenbo, Wang Haibin, Lu Jinhua, Sun Ming-an*; Cao Bin*. Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization. Nucleic Acids Research. 2023, 51(10):4745-4759.

2.Wenzhe Yu†, Beiang Zhang†, Xiao Hong, Han Cai, Yinan Wang, Jinhua Lu, Xiaoqian Hu*, Bin Cao*. Identification of desoxyrhapontigenin as a novel antiviral agent against congenital Zika virus infection. Antiviral Research. 2023, 211:105542.

3. Lida Fan†,Wenzhe Yu†, Beiang Zhang, Bin Cao, Mingfu Wang*, Xiaoqian Hu*. Distinctive effects of different types of advanced glycation end-products (AGEs) on liver glucose metabolism. Food Funct. 2022, 13(21):11298-11306.

4. Wenzhe Yu, Lida Fan, Mingfu Wang, Bin Cao*, Xiaoqian Hu*. Pterostilbene improves insulin resistance caused by advanced glycation end products (AGEs) in hepatocytes and mice. Mol Nutr Food Res. 2021, 65(15):e2100321. (Cover story)

5. Wenzhe Yu, Xiaoqian Hu, Bin Cao*. Viral Infections During Pregnancy: The Big Challenge Threatening Maternal and Fetal Health. Matern Fetal Med. 2021, 4(1):72-86.

6. Xiaoqian Hu, Mingfu Wang*, Fereidoon Shahidi*. Antiglycative and anti-inflammatory effects of lipophilized tyrosol derivatives. Food Production Processing and Nutrition. 2020, 2(1):28.

7. Yueliang Zhao, Hongyun Kong, Xu Zhang, Xiaoqian Hu*, Mingfu Wang*. The effect of Perilla (Perilla frutescens) leaf extracts on the quality of surimi fish balls. Food Science and Nutrition, 2019, 7(6): 2083-2090.

8. Wenzhe Yu, Xiaoqian Hu*, Mingfu Wang*. Pterostilbene inhibited advanced glycation end products (AGEs)-induced oxidative stress and inflammation by regulation of RAGE/MAPK/NF-κB in RAW264.7 cells. Journal of functional foods, 2018, 40: 272-279.

9. Yueliang Zhao†, Xiaoqian Hu†, Xinyuan Zuo, Mingfu Wang*. Chemopreventive effects of some popular phytochemicals on human colon cancer: A review. Food Funct., 2018, 9, 4548.

10. Yun Yao, Kehai Liu, Yueliang Zhao, Xiaoqian Hu*, Mingfu Wang. Pterostilbene and 4’-Methoxyresveratrol inhibited lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages. Molecules. 2018, 23(5), 1148.

11. Wenzhe Yu, Mengru Tao, Yueliang Zhao, Xiaoqian Hu*, Mingfu Wang*. 4’-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-κB and NLRP3 Inflammasome Pathway. Molecules 2018, 23(6), 1447.

12. Jing Teng, Yunlong Li, Wenzhe Yu, Yueliang Zhao, Xiaoqian Hu, Ning-ping Tao, Mingfu Wang*. Naringenin, a common flavanone, inhibits the formation of AGEs in bread and attenuates AGEs-induced oxidative stress and inflammation in RAW264.7 cells. Food chemistry, 2018, 269:35-42.