教育经历
2011/09-2016/06，维多利亚老品牌vic119生命科学学院，生物化学与分子生物学专业，博士
2007/09-2011/06，维多利亚老品牌vic119生命科学学院，生物技术专业，学士
科研与学术工作经历
2023/09-至今 维多利亚老品牌vic119，教授
2022/08-2023/09 维多利亚老品牌vic119，副教授
2020/01-2022/07 维多利亚老品牌vic119，助理教授
2017/11-2018/11 美国Scripps研究所，Professional Scientific Collaborator
2016/07-2019/12 维多利亚老品牌vic119，博士后
主要研究方向
1. 病毒性感染的免疫防治（疫苗、抗体、免疫机制）
2. 针对炎症、肿瘤的免疫治疗新靶标与抗体药物
3. 新型佐剂、VSV病毒载体等免疫增强技术
4. 乙肝治疗性抗体与治疗性疫苗
代表性学术论文（共同第一/通讯作者）：
(1) Qi RY#, Fu R#, Lei X#, He JH#, Jiang Y, Zhang L, Wu YT, Wang SL, Guo XR, Chen F, Nie MF, Yang M, Chen YY, Zeng J, Xu JJ, Xiong HL, Fang, MJ, Que YQ, Yao YL, Wang YB, Cao JL, Ye HM, Zhang YL, Zheng ZZ, Cheng T, Zhang J, Lin X*, Yuan Q*, Zhang TY*, Xia NS*. Therapeutic vaccine-induced plasma cell differentiation is defective in the presence of persistently high HBsAg levels. Journal of Hepatology, 2024 Feb 7:S0168-8278(24)00111-9.
(2) Fu R#, Qi RY#, Xiong HL#, Lei X#, Jiang Y#, He JH, Chen F, Zhang L, Qiu DK, Chen YY, Nie MF, Guo XR, Zhu YH, Zhang JL, Yue MX, Cao JL, Wang GS, Que YQ, Fang MJ, Wang YB, Chen YX, Cheng T, Ge SX, Zhang J, Yuan Q*, Zhang TY*, Xia NS*. Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects. Signal Transduction and Targeted Therapy, 2024 May 3;9(1):118.
(3) Zhang TY#, Guo XR#, Wu YT#, Kang XZ, Zheng QB, Qi RY, Chen BB, Lan Y, Wei M, Wang SJ, Xiong HL, Cao JL, Zhang BH, Qiao XY, Huang XF, Wang YB, Fang MJ, Zhang YL, Cheng T, Chen YX, Zhao QJ, Li SW, Chen PJ, Zhang J*, Yuan Q* and Xia NS*. A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice. Gut. 2020 Feb,69(2):343-354.
(4) Zhang TY#, Chen HY#, Cao JL#, Xiong HL, Li TL, Kang XZ, Zhao JH, Yin B, Yuan Q*, Xue D*, Xia NS*, Yuan YA. Structural and functional analyses of the Hepatitis B virus X protein BH3-like domain and its interaction with Bcl-xL. Nature Communications. 2019, 10:3192.
(5) Zhang TY#, Yuan Q#,*, Zhao JH, Zhang YL, Yuan LZ, Lan Y, Lo YC, Sun CP, Wu CR, Zhang JF, Zhang Y, Cao JL, Guo XR, Liu X, Mo XB, Luo WX, Cheng T, Chen YX, Tao MH, Shih JW, Zhao QJ, Zhang J, Chen PJ, Yuan YA*, Xia NS*, Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen, Gut, 2016, 65(4): 658-71.
(6) Jiang YC, Chen XQ, Ye XY, Wen C, Xu T, Yu C, Ning WJ, Wang GS, Xiang XC, Liu XM, Wang YL, Chen YZ, Liu X, Shi CR, Liu C, Yuan Q, Zhang TY*, Luo WX*, Xia NS*. A Dual-domain Engineered Antibody for Efficient HBV Suppression and Immune Responses Restoration. Advanced Science. 2024 Apr;11(15):e2305316.
(7) Zhang L#, Jiang Y#, He JH#, Chen JY#, Qi RY#, Yuan LZ#, Shao TG#, Zhao H#, Chen CJ, Chen YD, Wang XJ, Lei X, Gao QX, Zhuang CL, Zhou M, Ma J, Liu W, Yang M, Fu R, Wu YT, Chen F, Xiong HL, Nie MF, Chen YY, Wu K, Fang MJ, Wang YB, Zheng ZZ, Huang SJ, Ge SX, Cheng SC, Zhu HC, Cheng T, Yuan Q, Wu T*, Zhang J*, Chen YX*, Zhang TY*, Li CG*, Qi H*, Guan Y* and Xia NS*. Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters. Nature Communications 2023 Jul 11;14(1):4117.
(8) Xiong HL#, Sun H#, Wang SL#, Yuan LZ#, Liu LQ#, Zhu YH#, Zhang JL#, Huang Y, Qi RY, Jiang Y, Ma J, Zhou M, Ma Y, Fu R, Yan SP, Yue MX, Wu YT, Wei M, Wang YZ, Li TT, Wang YB, Zheng ZZ, Yu H, Cheng T, Li SW*, Yuan Q*, Zhang J*, Guan Y*, Zheng QB*, Zhang TY*, Xia NS*. The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2. Proc Natl Acad Sci USA, 2022, 119(34): e2204256119.
(9) Zhu FC#, Huang SJ#, Liu XH#, Chen Q#, Zhuang CL#, Zhao H#, Han JL#, Anjuli May Jaen AM, Thai Hung Do, Jonathan Grant Peter, Alexander Gonzalez Dorado, Louie S. Tirador, Gelza Mae A. Zabat, Ralph Elvi M. Villalobos, Gemalyn Pineda Gueco, Lauren Livia Greta Botha, Shirley Patricia Iglesias Pertuz, Tan JX, Zhu KX, Quan JL, Lin HY, Huang Y, Jia JZ, Chu XF, Chen JY, Chen YX, Zhang TY*, Su YY*, Li CG*, Ye XZ*, Wu T*, Zhang J*, Xia NS*, for the COVID-19-PRO-003 Study Team. Safety and efficacy of the intranasal spray SARS-CoV-2 vaccine dNS1-RBD: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med, 2023 Nov 15:S2213-2600(23)00349-1.
(10) Zhu FC#, Zhuang CL#, Chu K#, Zhang L#, Zhao H#, Huang SJ, Su YY, Lin HY, Yang CL, Jiang HM, Zang X, Liu DL, Pan HX, Hu YM, Liu XH, Chen Q, Song QQ, Quan JL, Huang ZH, Zhong GH, Chen JY, Han YL, Sun H, Cui LB, Li JX, Chen YX*, Zhang TY*, Ye XZ*, Li CG*, Wu T*, Zhang J*, Xia NS*, Safety and immunogenicity of a live-attenuated influenza virus vector-based intranasal SARS-CoV-2 vaccine in adults: randomised, double-blind, placebo-controlled, phase 1 and 2 trials, The Lancet Respiratory Medicine, 2022, 10(8): 749-760
(11) Wu YT#, Wang SJ#, Zhang YL#, Yuan LZ#, Zheng QB#, Wei M#, Shi Y#, Wang ZK, Ma J, Wang K, Nie MF, Xiao J, Huang ZH, Chen PW, Guo HL, Lan ML , Xu JJ, Hou WH, Hong YD, Chen DB, Sun H, Xiong HL, Zhou M, Liu C, Guo WJ, Guo HY, Gao JH, Gan CL, Li ZX, Zhang HT, Wang XR, Li SW, Cheng T, Zhao QJ, Chen YX, Wu T, Zhang TY*, Zhang J*, Cao H*, Zhu HC*, Yuan Q*, Guan Y*, Xia, N.*. Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine. Cell Host & Microbe, 2022, 30(12): 1732-1744 e7.
(12) Nie MF#, Wu SY#, Chen YY#, Wu YT#, Chen RT, Liu Y, Yue MX, Jiang Y, Qiu DK, Yang M, Wang ZK, Gao JH, Xiong HL, Qi RY, He JH, Zhang JL, Wang YB, Fang MJ, Que YQ, Yao YL, Li SW*, Zhang J*, Zhao QJ*, Yuan Q*, Zhang TY*, Xia NS*. Micronanoparticled risedronate exhibits potent vaccine adjuvant effects. Journal of Controlled Release. 2024 Jan:365:369-383.
(13) Lu J#, Lu GL#, Tan SD#, Xia J#, Xiong HL#, Yu XF#, Qi QQ, Yu X, Li L, Yu H, Xia NS, Zhang TY*, Xu YJ*, Lin JZ*. A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice. Cell Research. 2020 Oct,30(10):936-939.
(14) Wu YT#, Huang XF#, Yuan LZ#, Wang SJ#, Zhang YL#, Xiong HL#, Chen RR, Ma J, Qi RY, Nie MF, Xu JJ, Zhang ZG, Chen LQ, Wei M, Zhou M, Cai MP, Shi Y, Zhang L, Yu H, Hong JP, Wang ZK, Hong YD, Yue MX, Li ZL, Chen DB, Zheng QB, Li SW, Chen YX, Cheng T, Zhang J*, Zhang TY*, Zhu HC*, Zhao QJ*, Yuan Q*, Guan Y*, Xia NS*. A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters. Science Translational Medicine, 2021, 13(606): 1-15
承担科研项目情况：
(1) 国家自然科学基金优青项目，病毒性感染的免疫防治，2024.01-2026.12，在研，主持
(2) 国家自然科学基金专项项目，基于纳米铝乳剂和模式识别受体激动剂的复合型佐剂研究，2023.09-2025.08，在研，主持
(3) 国家自然科学基金面上项目，基于新型双膦酸盐佐剂和表位嵌合颗粒抗原的乙肝治疗性疫苗疗效与机制研究，2022.01-2025.12，在研，主持
(4) 国家自然科学基金重大项目，保护性体液免疫形成及维持机制，2020.01-2024.12，在研，骨干
(5) 福建省杰出青年科学基金项目，β属冠状病毒B亚群广谱中和表位鉴定及其在疫苗和抗体研发中的应用，2020.08-2023.08，已结题，主持
(6) 国家自然科学基金青年项目，慢性乙肝病人基线血清HBV感染力与治疗应答的相关性及其病毒学机制研究, 2018.01-2020.12, 已结题, 主持
