周子健教授主要从事分子影像和医工交叉领域的应用基础研究，研究兴趣包括（1）免疫细胞功能活性的在体可视化、分子调控及诊疗研究；（2）铁死亡分子影像探针的开发及相关疾病的诊疗研究；（3）核素类探针/药物的临床转化开发和药效评估。迄今共发表学术论文90余篇，论文总被引用14000余次、H因子60。近五年，以通讯作者或第一作者在包括Nat. Nanotechnol.、Sci. Adv.、Nat. Commun.、Angew. Chem. Int. Ed.、Clin. Transl. Med.等杂志发表多篇论文，4篇入选ESI高被引论文。担任Chinese Chemical Letters（中国化学快报）杂志高级编委、Chemical & Biomedical Imaging（美国化学会）杂志青年顾问委员（ECAB）、iRADIOLOGY杂志青年编委、中国生物材料学会纳米生物材料分会委员、中国抗癌协会医工整合专业委员会委员等职务，入选斯坦福大学发布的2023年度前2%科学家年度科学影响力排行榜。主持国家自然科学基金2项以及企业委托开发的横向项目多项，主要负责用于IND申报核素类药物的药学和非临床部分研究，已有3项参与的新药申报项目获得临床试验批件。
工作与教育经历
2024.5 –教授、博导/硕导 维多利亚老品牌vic119
2020.10 –2024.4 副教授、博导/硕导 维多利亚老品牌vic119
2015.11 – 2020.9 博士后
Laboratory of Molecular Imaging and Nanomedicine (LOMIN),
National Institute of Biomedical Imaging and Bioengineering (NIBIB),
National Institutes of Health (NIH)
2010.9 – 2015.9 博士，化学生物学，化学化工学院，维多利亚老品牌vic119
2006.9 – 2010.7 学士，制药工程学，药学与生物工程学院，重庆理工大学
1. Coassembly Nanomedicine Mediated by Intermolecular Interactions Between Methotrexate and Baricitinib for Improved Rheumatoid Arthritis Treatment. Xiong, H.; Zhang, H.; Qin, Y.; Ye, J.; Zeng, F.; Xie, P.; Shi, C.; Luo, C.; Xu, W.; Yu, C.*; Zhou, Z.* Chen, X.* ACS Nano 2024, 18, 8337-8349.
2. Magnetic Resonance Imaging Nanoprobe Quantifies Nitric Oxide for Evaluating M1/M2 Macrophage Polarization and Prognosis of Cancer Treatments. Liu, X.; Wang, M.; Jiang, Y.; Zhang, X.; Shi, C.; Zeng, F.; Qin, Y.; Ye, J.; Hu, J.; Zhou, Z.* ACS Nano 2023, 17, 24854-24866.
3. Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics. Shi, C.; Zhang, Q.; Yao, Y.; Zeng, F.; Du, C.; Nijiati, S.; Wen, X.; Zhang, X.; Yang, H.; Chen, H.; Guo, Z.; Zhang, X.; Gao, J.; Guo, W.*; Chen, X.*; Zhou, Z.* Nat. Nanotechnol. 2023, 18, 86-97.
国家自然科学基金委员会科学传播与成果转化中心：
https://www.nsfc.gov.cn/csc/20340/20343/64350/index.html
Faculty Opinions (F1000 Prime)：
https://facultyopinions.com/article/742459711
4. Ferroptosis MRI for Early Detection of Anticancer Drug-Induced Acute Cardiac/KidneyInjuries. Zeng, F.; Nijiati, S.; Liu, Y.; Yang, Q.; Liu, X.; Zhang, Q.; Chen, S.; Su, A.; Xiong, H.; Shi, C.; Cai, C.; Lin, Z.; Chen, X.*; Zhou, Z.* Sci. Adv. 2023, 9, eadd8539.
5. Fe(II)-Targeted PET/19F MRI Dual-Modal Molecular Imaging Probe for Early Evaluation of Anticancer Drug-Induced Acute Kidney Injury. Nijiati, S.;Zeng, F.; Zuo, C.; Zhang, Q.; Du, C.; Shi, C.; Gao, J.*; Zhou, Z.* Mol. Pharmaceut. 2023, 20, 5185-5194.
6. Theranostics on the immunoactivity of T cells. Shi, C.; Zhang, X.; Liu, X.; Chen, X.*; Zhou, Z.* Clin. Transl. Med. 2023, 9, e1421. (Commentary Invited by the Editor-in-Chief)
7. Ferroptosis Detection: From Approaches to Applications. Zeng, F.; Nijiati, S.; Tang, L.; Ye, J.; Zhou, Z.*; Chen, X.* Angew. Chem. Int. Ed. 2023, e202300379. (Invited Review)
8. Boosting the Immunoactivity of T Cells by Resonant Thermal Radiation from Electric Graphene Films for Improved Cancer Immunotherapy. Shi, C.; Fu, W.; Zhang, X.; Zhang, Q.; Zeng, F.; Nijiati, S.; Du, C.; Liu, X.; Wang, M.; Yao, Y.; Huang, H.; Zheng, N.; Chen, X.; Wu, B.*; Zhou, Z.* Adv. Therap. 2023, 2200163.
9. Coordinating the Mechanisms of Action of Ferroptosis and Photothermal Effect for Cancer Theranostics. Zeng, F.; Tang, L.*; Zhang, Q.; Shi, C.; Huang, Z.; Nijiati, S.; Chen, X.*; Zhou, Z.*Angew. Chem. Int. Ed. 2022, 61, e202112925.
10. Cycloacceleration of reactive oxygen species generation based on exceedingly small magnetic iron oxide nanoparticles for tumor ferroptosis therapy. Zhou, H.; Lu, X.; Du, C.; Zhou, Z.*; Feng, J.; Liang, Z.; Xu, Y.*; Qiu, X.*; Shen, Z.* Small 2022, 18, e202202705.
11. Zhou, Z.*; Du, C.; Zhang, Q.; Yu, G.; Zhang, F.*; Chen, X.* Exquisite Vesicular Nanomedicine by Paclitaxel Mediated Co-assembly with Camptothecin Prodrug. Angew. Chem. Int. Ed. 2021, 60, 21033-21039.
12. Shi, C.; Zhou, Z.*; Lin, H.*; Gao, J.* Imaging beyond Seeing: Early Prognosis of Cancer Treatment. Small Methods 2021, 6, 2001025. (Invited Review)
13. Zhou, Z.; Deng, H.; Yang, W.; Wang, Z.; Lin, L.; Munasinghe, J.; Jacobson, O.; Liu, Y.; Tang, L.; Ni, Q.; Kang, F.; Liu, Y.; Niu, G.; Bai, R.; Qian, C.; Song, J.*; Chen, X.* Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging. Nat. Commun. 2020, 11, 3032.
14. Zhou, Z.†; Tian, R.†; Wang, Z. Y.; Yang, Z.; Liu, Y. J.; Liu, G.; Wang, R. F.; Gao, J. H.; Song, J.*; Nie, L.*; Chen, X.* Artificial Local Magnetic Field Inhomogeneity Enhances T2 Relaxivity. Nat. Commun. 2017, 8, 15468.
15. Tang, L.; Wang, Z.; Mu, Q.; Yu, Z.*; Jacobson, O.; Li, L.; Yang, W.; Huang, C.; Kang, F.; Fan, W.; Ma, Y.; Wang, M.*; Zhou, Z.*; Chen, X.* Targeting Neutrophils for Enhanced Cancer Theranostics. Adv. Mater. 2020, 32 (33), 2002739.
16. Zhou, Z.; Chan, A.; Wang, Z.; Huang, X.; Yu, G.; Jacobson, O.; Wang, S.; Liu, Y.; Shan, L. L.; Dai, Y.; Shen, Z.; Lin, L. S.; Chen, W.; Chen, X.* Synchronous Chemoradiation Nanovesicles by X-ray Triggered Cascade of Drug Release. Angew. Chem. Int. Ed. 2018, 57, 8463-8467.
17. Zhou, Z.†; Song, J.†; Tian, R.; Yang, Z.; Yu, G.; Lin, L.; Zhang, G.; Fan, W.; Zhang, F.; Niu, G.; Nie, L.*; Chen, X.*, Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy.Angew. Chem. Int. Ed. 2017, 56,6592-6596. (ESI Highly Cited Paper)
18. Zhou, Z.; Yang, L.; Gao, J.*; Chen, X.* Structure–Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging. Adv. Mater. 2019, 31, 1804567. (Invited Review) (ESI Highly Cited Paper)
19. Zhou, Z.; Song, J.; Nie, L.*; Chen, X.*, Reactive Oxygen Species Generating Systems Meeting Challenges of Photodynamic Cancer Therapy. Chem. Soc. Rev. 2016, 45, 6597-6626. (Invited Review) (ESI Highly Cited Paper)
20. Shen, Z.; Song, J.; Yung, B; Zhou, Z.*; Wu, A.*; Chen, X.*, Emerging Strategies of Cancer Therapy Based on Ferroptosis. Adv. Mater. 2018, 30, 1704007. (Invited Review) (Featured as Frontispiece Article) (ESI Highly Cited Paper)
21. Zhou, Z.*; Ni, K.; Deng, H.; Chen, X.* Dancing with Reactive Oxygen Species Generation and Elimination in Nanotheranostics for Disease Treatment. Adv. Drug Deliv. Rev. 2020, 158, 73-90. (Invited Review)
22. Song, J.; Lin, L.; Yang, Z.; Zhu, R.; Zhou, Z.*; Li, Z.*; Wang, F.; Chen, J.; Yang, H.*; Chen, X.* Self-Assembled Responsive Bilayered Vesicles with Adjustable Oxidative Stress for Enhanced Cancer Imaging and Therapy. J. Am. Chem. Soc. 2019, 141, 8158.
23. Tang, L.; Yang, Z.; Zhou, Z.*; Ma, Y.; Kiesewetter, D.; Wang, Z.; Fan, W.; Zhu, S.; Zhang, M.; Tian, R.; Lang, L.; Niu, G.; Zhang, X.*; Chen, X.* A Logic-Gated Modular Nanovesicle Enables Programmable Drug Release for On-Demand Chemotherapy. Theranostics. 2019, 9, 1358-1368.
24. Zhou, Z.; Shen, Z.*; Chen, X.* Tale of Two Magnets: An Advanced Magnetic Targeting System. ACS Nano 2020, 14, 7-11. (Perspective)
25. Zhou, Z.; Bai, R.; Munasinghe, J.; Shen, Z.; Nie, L.*; Chen, X.*, T1–T2 Dual–Modal Magnetic Resonance Imaging: From Molecular Basis to Contrast Agents. ACS Nano 2017, 11, 5227–5232. (Perspective)
26. Zhou, Z.; Bai, R.*; Wang, Z.; Bryant, H.; Lang, L.; Merkle, H.; Munasinghe, J.; Tang, L.; Tang, W.; Tian, R.; Yu, G.; Ma, Y.; Niu, G.; Gao, J.*; Chen, X.* An Albumin-Binding T1-T2 Dual-modal MRI Contrast Agents for Improved Sensitivity and Accuracy in Tumor Imaging. Bioconjugate Chem. 2019, 30, 1821-1829.
27. Zhou, Z.; Hu, R.; Wang, L.; Sun C.; Fu, G.; Gao, J.*, Water Bridge Coordination on The Metal-Rich Facets of Gd2O3 Nanoplates Confers High T1 Relaxivity. Nanoscale 2016, 45,17887-17894.
28. Zhou, Z.†; Wu, C. Q.†; Liu, H. Y.; Zhu, X. L.; Zhao, Z.; Wang, L.; Xu, Y.; Ai, H.; Gao, J. H.*, Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Nano 2015, 9, 3012-3022.
29. Zhou, Z.; Zhu, X. L.; Wu, D.; Chen Q.; Huang, D.; Sun, C.; Xin, J.; Ni, K. Y.; Gao, J.*, Anisotropic Shaped Iron Oxide Nanostructures: Controlled Synthesis and Proton Relaxation Shortening Effects. Chem. Mater. 2015, 27, 3505-3515.
30. Zhou, Z.†; Liu, H.†; Chi, X.†; Chen, J.; Wang, L.; Sun, C.; Chen, Z.; Gao, J. H.*, A Protein-Corona-Free T1–T2 Dual-Modal Contrast Agent for Accurate Imaging of Lymphatic Tumor Metastasis. ACS Appl. Mater. Interfaces 2015, 7, 28286.
31. Zhou, Z.†; Zhao, Z.†; Zhang, H.; Wang, Z.; Chen, X. Y.; Wang, R.; Chen, Z.; Gao, J. H.*, Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.
32. Zhou, Z.; Wang, L. R.; Chi, X.; Bao, J. F.; Yang, L.; Zhao, W.; Chen, Z.; Wang, X.; Chen, X. Y.; Gao, J. H.*, Engineered Iron-Oxide-Based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging. ACS Nano 2013, 7, 3287-3296.
33. Zhou, Z.; Huang, D. T.; Bao, J.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.*, A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.
Book Chapter
1. Zhou, Z.; Chen, X.*, Magnetic Nanomaterials for Diagnostics. Magnetic Nanomaterials - Fundamentals, Synthesis and Applications, 365-392. John Wiley & Sons (2017)
学术兼职
《Chinese Chemical Letters》杂志高级编委
《Chemical & Biomedical Imaging》(ACS) 杂志青年顾问委员 (ECAB)
《iRADIOLOGY》杂志青年编委
中国生物材料学会纳米生物材料分会委员
中国抗癌协会第一届医工整合专业委员会委员
