教育背景
2001/9-2007/1，中国科学院大连化学物理研究所生物技术部，硕博连读
1997/9-2001/7 中国地质大学（武汉），本科
工作经历
2019/4-至今, 维多利亚老品牌vic119, 维多利亚老品牌vic119, 副教授
2010/7-2019/3，中国科学院城市环境研究所，城市环境和健康重点实验室，副研究员
2009/6-2010/6，加拿大卫生部，化学品安全局，访问学者
2007/4-2009/4，维多利亚老品牌vic119, 化学化工学院，博士后
讲授课程
《环境卫生学》、《环境卫生学实验与实践》、《卫生化学》、《分析化学》、《流行病学》、《专业英语与应用》、《生活中的毒理学》
主要研究领域
1. 系统流行病学和毒理学：基于转录组、肠道宏基因组、表观遗传组、蛋白质组以及代谢组，将暴露组与系统流行病学相结合，研究环境因素（如大气污染、绿地、光污染、内分泌干扰物、持久性有机污染物等）以及营养、生活方式等因素与疾病的关联及分子机制。通过这种综合方法，旨在精准预防疾病、促进健康。此外，还利用细胞和动物模型研究环境暴露因素的分子毒性机制。
2. 临床诊断标志物发现及诊断模型：通过多组学方法寻找生物标志物、生物靶点和代谢途径，深入探讨疾病的发病机制，建立早期预测和高危个体筛选模型，为个性化医疗和转化医学提供科学支持。基于标志物的发现，开发体外诊断方法并实现临床应用。
3. 公共卫生应急平台建设：研究复杂样品（如食品、生物样品、环境样品）中有害物质的高通量分析技术，旨在提升公共卫生应急响应能力。
招生兴趣：
1. 预防医学、卫生检验与检疫、统计学、健康大数据等相关专业优秀的本科生、研究生；
2. 掌握一种或多种编程语言，如R、Python等；
3. 热爱科研、责任心强、踏实进取，具有良好的统计学基础以及英文写作能力。
诚挚欢迎对以上研究领域感兴趣的同学报考硕士、博士或博士后。
代表性成果
承担科研项目情况：
1. 国家自然科学基金面上项目，22076157，砷致肝脏糖脂代谢紊乱促发/加重妊娠期糖尿病的机理及干预研究、63万元、主持。
2. 国家自然科学基金面上项目，21677141，青春期砷暴露干扰雄性大鼠HPT轴内分泌/代谢通路的生殖毒性研究、65万元、主持。
3. 国家自然科学基金青年项目，21407143、饮水型砷暴露对幼鼠海马和皮质DNA甲基化/去甲基化过程的影响及干扰机制研究、26万元、主持。
4. 科技部国家重点研发计划、2017YFC0211602、大气污染对呼吸和心血管系统健康影响的早期识别技术、2967万元、骨干成员。
5. 维多利亚老品牌vic119校长基金项目，20720190074、基于“暴露组-代谢组-精子质量”全关联分析的男性生殖健康研究、75万元、主持。
6. 中国科学院青年创新促进会人才项目，2015/01-2018/12、60万元、主持。
7. 中国科学院知识创新工程重要方向项目，KZCX2-EW-QN408、基于联合组学的全氟辛烷类污染物的人类肝脏细胞毒性研究、120万元、主持。
8. 厦门市科技计划项目，3502Z20112017、乳及乳制品中有机污染物的高通量筛查检测技术研究、100万元、主持。
9. 福建省自然科学基金面上项目，2018J01021，利用系统生物学方法研究大气颗粒物对肺部微生物及其与宿主分子交互作用网络的干扰效应及机理、6万元、主持。
10. 福建省自然科学基金面上项目，2013J01063、福建省典型酚类环境雌激素的膳食暴露和健康风险、6万元、主持。
11. 中国科学院城市环境研究所青年人才领域前沿项目，IUEZD201401、基于下丘脑-垂体-睾丸性腺轴的内分泌(激素)和代谢干扰效应及其机制研究、40万元、主持。
12. 福建省海洋藻类活性物质制备与功能开发重点实验室开放课题，硫酸酯海藻多糖致机体结肠炎的代谢组学研究，2022KF09、3万元、主持。
13. 生物样本代谢组学检测，校合20223160A0787、30万元、主持。
14. 基于灌口镇老年队列的慢性肾病的整合组学疾病标志物筛选及诊疗模型构建，校合20223160A0027、28.7万元、主持。
15. “典型地区总暴露研究”课题生物样本的代谢组，XDHT2020606A、10万元、主持。
16. 呋喃二甲酸的纯度鉴定分析方法，校合20223160A0080、9.9万元、主持。
17. 组织和血液样本代谢组学检测，校合20233160A0436、4.8万元、主持。
近年来发表的代表性论文：*通讯作者，#第一作者
1. Zhong-Hua Lu#, Chong Liu#, Yu-Jie Chen, Ying-Jun Chen, Xiao-Ning Lei, Li-Jing Cai, Hai-Xia Zhou, Hao Chang, Miao Zhu, Yi-Xin Wang*, Jie Zhang*, Gestational Exposure to PM2.5 and Specific Constituents, Meconium Metabolites, and Neonatal Neurobehavioral Development: A Cohort Study, Environmental Science & Technology. 2024, 58: 9980–9990.
2. Shijia Liang, Zhonghua Lu, Lijing Cai, Miao Zhu, Haixia Zhou, Jie Zhang*, Multi-Omics Analysis Reveals Molecular Insights into the Effects of Acute Ozone Exposure on Lung Tissues of Normal and Obese Male Mice, Environment International, 2024, 183:108436.
3. Wenjia Lu#, Chonggui Jiang, Yajie Chen, Zhonghua Lu, Xueli Xu, Liting Zhu, Haotong Xi, Guozhu Ye, Changzhou Yan, Jinsheng Chen, Jie Zhang*, Li Zuo*, Qiansheng Huang*, Altered metabolome and microbiome associated with compromised intestinal barrier induced hepatic lipid metabolic disorder in mice after subacute and subchronic ozone exposure, Environment International, 2024, 185:108559.
4. Zhong-Hua Lu#, Bin Sun#, Yi-Xin Wang*, Ya-Ru Wu, Yu-Jie Chen, Sheng-Zhi Sun, Shi-Jia Liang, Song Xu, Hao Chang, Heng-Gui Chen, Jie Zhang*, Ozone exposure associates with sperm quality indicators: Sperm telomere length as a potential mediating factor, Journal of Hazardous Materials. 2023, 459: 132292.
5. Rui Guo#, Qisheng Zhong, Jiaqi Liu, Peiming Bai, Zongpeng Wang, Jieling Kou, Peijie Chen*, Jie Zhang*, Bo Zhang*. Polarity-extended liquid chromatography-triple quadrupole mass spectrometry for simultaneous hydrophilic and hydrophobic metabolite analysis, Analytica Chimica Acta 2023, 1277: 341655.
6. Yiqin Zhang#, Chen Tang#*, Yuwen Liu#, Hanxiang Jiang, Jiaosheng Lu, Zhonghua Lu, Liping Xu, Siyu Zhang, Lina Zhou, Jing Ye, Xianfa Xuan, Ting Wu, Xia Cao, Benhua Zhao, Liangquan Lin, Yuxin Wang*, Jie Zhang*,Long-term ozone exposure was negatively associated with estimated glomerular filtration rate in Chinese middle-aged and elderly adults. Chemosphere 2023, 341：140040
7. Tasawar Khanam#, Shijia Liang#, Song Xu, Syed Ali Musstjab Akber Shah Eqani*, Mustafa Nawaz Shafqat, Hifza Rasheed, Nazia Bibi, Heqing Shen, Jie Zhang*, Arsenic exposure induces urinary metabolome disruption in Pakistani male population, Chemosphere 2023, 312: 137228.
8. Song Xu#, Yaru Wu, Yujie Chen, Wenqing Lu, Yi-Xin Wang⁎, Biling Gao, Jie Zhang ⁎, Environmental metal exposure, seminal plasma metabolome and semen quality: Evidence from Chinese reproductive-aged men, Science of the Total Environment 2022, 838: 155860.
9. Xiaoyan Du, Lianzhong Luo, Qingyu Huang, Jie Zhang⁎, Cortex metabolome and proteome analysis reveals chronic arsenic exposure via drinking water induces developmental neurotoxicity through hnRNP L mediated mitochondrial dysfunction in male rats, Science of the Total Environment 2022, 820: 153325.
10. Chen Tang#, Hanxiang Jiang#, Bin Zhao#, Yi Lin, Shengnan Lin, Tianmu Chen, Yanhua Su, Yiqin Zhang, Lina Zhou, Lianmeng Li, Jincheng Lin, Zhonghua Lu, Yao Wang, Zeyu Zhao, Longjian Liu, Yuxin Wang*, Jie Zhang*, Heqing Shen*, The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study, Journal of Translational Medicine 2022, 20:108.
11. Xuejingping Han#, Meiping Tian#, Pavel V. Shliaha, Jie Zhang*, Shoufang Jiang, Bingru Nan, Md Nur Alam, Ole N. Jensen*, Heqing Shen, Qingyu Huang*, Real-world particulate matters induce lung toxicity in rats fed with a high-fat diet: Evidence of histone modifications, Journal of Hazardous Materials 2021, 416: 126182.
12. Xiaoyan Du, Jie Zhang⁎, Xi Zhang, Karl-Werner Schramm, Bingru Nan, Qingyu Huang, Meiping Tian, Heqing Shen⁎, Persistence and reversibility of arsenic-induced gut microbiome and metabolome shifts in male rats after 30-days recovery duration, Science of the Total Environment 2021, 776: 145972.
13. Tasawar Khanam, Syed Ali Musstjab Akber Shah Eqani, Jie Zhang⁎, Heng Wang, Yongli Zhang, Jianbo Yang, Muhammad Sadiq, Hifza Rasheed, Heqing Shen⁎, Urinary profiles of selected metals and arsenic and their exposure pathway analysis in four large floodplains of Pakistan, Science of the Total Environment 2020, 737: 139586.
14. Yi-Xin Wang, Yan Wu, Heng-Gui Chen, Peng Duan, Liang Wang, He-Qing Shen, Wen-Qing Lu, Bin Sun, Qi Wang, Bo Zhang, Jorge E. Chavarro, Jie Zhang(*), An Pan(*), Seminal Plasma Metabolome in Relation to Semen Quality and Urinary Phthalate Metabolites among Chinese Adult Men, Environment International, 2019, 129: 354–363.
15. Yan Wu(#), Jie Zhang(#), Siyuan Peng, Xiaofei Wang, Lianzhong Luo, Liangpo Liu, Qingyu Huang, Meiping Tian, Xueqin Zhang(*), Heqing Shen(*), Multiple elements related to metabolic markers in the context of gestational diabetes mellitus in meconium, Environment International, 2018, 121: 1227–1234.
16. Jie Zhang(*), Liangpo Liu, Xiaofei Wang, Qingyu Huang, Meiping Tian, and Heqing Shen(*), Low-Level Environmental Phthalate Exposure Associates with Urine Metabolome Alteration in a Chinese Male Cohort, Environmental Science & Technology, 2016, 50: 5953-60.
17. Jie Zhang, Heqing Shen(*), Weipan Xu, Yankai Xia, Dana Boyd Barr, Xiaoli Mu, Xiaoxue Wang, Liangpo Liu, Qingyu Huang, and Meiping Tian, Urinary Metabolomics Revealed Arsenic Internal Dose-related Metabolic Alterations: a Proof-of-Concept Study in a Chinese Male Cohort, Environmental Science & Technology, 2014, 48(20): 12265-74.
18. Xiaoyan Du, Meiping Tian, Xiaoxue Wang, Jie Zhang(*), Qingyu Huang, Liangpo Liua, Heqing Shen(*), Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water, Environmental Pollution, 2018, 234:590-600.
19. Xiaofei Wang, Liangpo Liu, Weibing Zhang(*), Jie Zhang(*), Xiaoyan Du, Qingyu Huang, Meiping Tian, Heqing Shen(*), Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative /nitrosative stress in humans, Environmental Pollution, 2017, 229: 168-176.
20. Xiaofei Wang, Shoufang Jiang, Ying Liu, Xiaoyan Du, Weibing Zhang(*), Jie Zhang(*), Heqing Shen(*),Comprehensive pulmonary metabolome responses to intratracheal instillation of airborne fine particulate matter in rats, Science of the Total Environment, 2017, 592：41-50.
21. Xiaofei Wang(#), Jie Zhang(#), Weipan Xu, Qingyu Huang, Liangpo Liu, Meiping Tian, Yankai Xia, Weibing Zhang(*), Heqing Shen(*), Low-level environmental arsenic exposure correlates with unexplained male infertility risk, Science of the Total Environment, 2017, 571(15): 307~313.
22. Jie Zhang(*), Xiaoli Mu, Weipan Xu, Francis L. Martin, Ambreen Alamdar, Liangpo Liu, Meiping Tian, Qingyu Huang, Heqing Shen(*), Exposure to Arsenic via Drinking Water Induces 5-Hydroxymethylcytosine Alteration in Rat, Science of Total Environment, 2014, 497: 618-625.
23. Jie Zhang, Zhenzhen Huang, Minjian Chen, Yankai Xia, Francis L Martin, Weipan Xu, Wei Hang, Heqing Shen(*), Urinary Metabolome Identifies Signatures of Oligozoospermic Infertile Men, Fertility and Sterility, 2014, 102(1): 44-53.
24. Siyuan Peng(#), Jie Zhang(#), Liangpo Liu, Xueqing Zhang, Qingyu Huang, Ambreen Alamdar, Meiping Tian, Heqing Shen (*), Newborn Meconium and Urinary Metabolome Response to Maternal Gestational Diabetes Mellitus: A Preliminary Case-Control Study, Journal of Proteome Research, 2015, 14, 1799-1809.
25. Jie Zhang, Zhenzhen Huang, Yankai Xia, Francis L Martin, Wei Hang, Heqing Shen(*), Metabolomic Analysis Reveals a Unique Urinary Pattern in Normozoospermic Infertile Men, Journal of Proteome Research, 2014, 13(6): 3088-99.
26. Xiaoxue Wang, Xiaoli Mu, Jie Zhang(*), Qingyu Huang, Ambreen Alamdar, Meiping Tian, Liangpo Liu, Heqing Shen(*), Serum metabolomics reveals arsenic exposure disrupted lipid and amino acid metabolism in rat: a step forward in understanding chronic arsenic toxicity, Metallomics, 2015, 7(3): 544-552.
27. Qingyu Huang, Jie Zhang(*), Francis L Martin, Siyuan Peng, Meiping Tian, Xiaoli Mu, Heqing Shen(*), Perfluorooctanoic Acid Induces Apoptosis through the p53-Dependent Mitochondrial Pathway in Human Hepatic Cells: A Proteomic Study, Toxicology Letters, 2013, 223(2): 211-220.
28. Xiaoxue Wang, Jie Zhang(*), Qingyu Huang, Ambreen Alamdar, Meiping Tian, Liangpo Liu, Heqing Shen(*), Serum Metabolomics Analysis Reveals Oral Exposure to Benzo(a)pyrene Impaired Lipid Metabolism in Rats, Molecular Biosystems, 2015, 11: 753-759.
29. Qingyu Huang, Jie Zhang(*), Siyuan Peng, Heqing Shen(*), Proteomic analysis of perfluorooctane sulfonate-induced apoptosis in human hepatic cells using the iTRAQ technique, Journal of Applied Toxicology, 2014, 34(12): 1342-51.
30. Qingyu Huang, Jie Zhang(*), Siyuan Peng, Meiping Tian, Jinsheng Chen, Heqing Shen(*), Effects of Water Soluble PM2.5 Extracts Exposure on Human Lung Epithelial cells (A549): a Proteomic Study, Journal of Applied Toxicology, 2014, 34(6): 675-687.
31. Siyuan Peng, Lijuan Yan, Jie Zhang(*), Zhanlin Wang, Meiping Tian, Heqing Shen(*), An Integrated Metabonomics and Transcriptomics Approach to Understanding Metabolic Pathway Disturbance Induced by Perfluorooctanoic acid, Journal of Pharmaceutical and Biomedical Analysis, 2013, 86: 56-64.
32. Jie Zhang, Lijuan Yan, Meiping Tian, Qingyu Huang, Siyuan Peng, Sijun Dong(*), Heqing Shen(*), The Metabonomics of Combined Dietary Exposure to Phthalates and Polychlorinated Biphenyls in Mice, Journal of Pharmaceutical and Biomedical Analysis, 2012, 66: 287-297.
